Barcelona coach Gerardo Martino needs to find a quick fix for whatever is ailing his team or his first season in charge at the Nou Camp is likely to end without major silverware.
Setien's complaint piled yet more pressure on president Josep Maria Bartomeu less than an hour after a group seeking his removal announced they had gathered enough signatures to force a vote of no-confidence against him.
Pep Guardiola's formidable managerial skills will be put to the test again when his stuttering ManchesterCity side visit his former club Barcelona in a top-of-the-bill Champions League clash on Wednesday.
Barcelona finished three points behind Real Madrid last season but there is concern the gap between Spain's biggest two sides could be far larger this season.
Manager Mauricio Pochettino has reiterated his happiness at Tottenham Hotspur in some of his first public comments after he emerged as a leading candidate to replace Zinedine Zidane at Real Madrid.
When Barcelona lost to Chelsea in pre season friendly, Neymar was busy holidaying in Ibiza, Spain.
Barcelona star Neymar will miss the Clasico after receiving a three-match ban following his red card against Malaga, dealing a big blow to the Catalans who lie three points behind Real Madrid having played a game more than their rivals.
Lionel Messi will be "like a bull" when he returns after almost two months out with a thigh injury, his Barcelona teammate Cesc Fabregas predicted ahead of Sunday's La Liga match at home to Elche.
The hard-fought win took Zinedine Zidane's side on to 77 points after 34 games, seven clear of second-placed Barca who visit in-form Villarreal later on Sunday.
Israeli President Shimon Peres inadvertently kicked a ball straight into the midriff of startled Barcelona striker Lionel Messi as he launched a soccer event by the Spanish league champions in Tel Aviv on Sunday.
China's Li Shixin drew inspiration from the spectacular hilltop setting to help secure his second consecutive men's one-metre springboard title at the world championships in Barcelona on Monday.
Valverde refused to answer questions about the club's interest in Neymar and lamented the fact that the Spanish transfer window does not shut before the season starts, as it does in England.
Brazilian Kaka looked a player reborn while producing a superb display in AC Milan's 1-1 Champions League draw with Barcelona on Tuesday.
Barcelona right back Dani Alves has completed his move to Italian champions Juventus on a two-year contract, the Turin-based club said on Monday. The 33-year-old Brazilian had earlier announced he would leave Barca as a free agent after eight successful seasons, during which he won 23 titles.
Barcelona forwards Ousmane Dembele and Lionel Messi fired the Catalans to a confidence-boosting 2-0 win at in-form Sevilla on Saturday to keep the pressure on La Liga leaders Atletico Madrid.
Barcelona's payment of 40 million euros to a company owned by Neymar's father as part of the Brazil forward's 57.1 million euros transfer fee is being investigated by Spanish state prosecutors for misappropriation of funds.
Their stunning football has been a pleasure to watch for both fans and neutrals this season.
The suspension was handed down by the Competition Committee of the Spanish Football Federation (RFEF) on Thursday and applies to Cup matches only.
Despite their first-leg advantage, Pochettino warned against complacency and said he wanted his team to play for another win, although they have had one day less to prepare than the Germans.
Paris St Germain suffered their first defeat of the season when they were beaten 2-0 at Stade Rennais on Sunday to drop their first Ligue 1 points of the season.
Images from football action around European leagues played on Sunday
Barcelona are keen to sign the Brazilian playmaker, who joined Liverpool from Inter Milan for 8.5 million pounds ($11.03 million) in 2013, and have already had an initial bid worth 80 million euros rejected by Liverpool last month.
IMAGES from the Champions League matches played on Tuesday.
Barcelona footballer Xavi has reportedly hinted that he may quit his current club.
Barcelona announced on Tuesday the signing of Spain forward Paco Alcacer from Valencia on a five-year contract. He moves to the Nou Camp on his 23rd birthday for a fee of 30 million euros ($33.5 million) and is likely to be the Spanish champions' last signing in the transfer window.
Images from the Champions League matches played between Bayern Munich and Barcelona in Munich on Wednesday.
The Catalans, winners of the trophy in 2009 and 2011, had no answer to Bayern's power, speed, pressing and resolute defence as they slumped to their heaviest defeat for almost six years and matched their worst result in European competition.
Barcelona forward Lionel Messi, who has been struggling with a hamstring strain, is likely to face Bayern Munich in Tuesday's Champions League tie but his participation will be decided after a final training session, the Catalans said on Monday.
Real are unbeaten since February, winning 10 of their last 12 games. In contrast, Barcelona have won just two of their previous five in all competitions and were dumped out of Europe in midweek.
Champions Real Madrid were beaten at home by promoted Cadiz, while Barcelona fell to their first defeat in La Liga under new coach Ronald Koeman as they lost to Getafe.
Barcelona are on the verge of Champions League elimination after being thrashed 3-0 by Juventus in Turin on Tuesday, and few believe lightning can strike twice.
Lionel Messi scored twice to earn Barcelona a 2-0 derby win over Espanyol and send them 13 points clear at the top of La Liga on Saturday.
A summary of Wednesday night's action in the UEFA Champions League.
Images from the Champions League matches played across Europe on Wednesday.
Rather like tennis's serial record breaker Roger Federer, Barcelona striker Lionel Messi cannot seem to finish a soccer match without ticking off another milestone.
'The pandemic has caused football to change a lot, and for the worse. You can see it in the matches, and I hope this all ends soon and we can get fans back into the stadiums and return to normality.'
Barcelona wasted their first chance to reach the Champions League last 16 after a surprise defeat by Celtic but Manchester United edged through and six-goal Bayern Munich rocketed closer to progression on Wednesday.
News of all that transpired on and off the football field.
Images from the football matches played across Europe on Wednesday.